In 2021, the global hyperpigmentation disorder therapy market was worth $4.5 billion. During the forecast period of 2023 to 2030, it is anticipated that the global market will grow at a CAGR of 9%. It is anticipated that by the end of 2031, the global market for the treatment of hyperpigmentation disorders will exceed $10 billion. During the forecast period, the market is anticipated to be driven by factors such as an increase in investment in research and development of novel advanced technologies, a decline in the social stigma surrounding pigmentation, an increase in the prevalence of hyperpigmentation-related disorders, and a rise in awareness regarding skin rejuvenation and treatment options. Globally active companies are in a position to capitalize on the opportunities created by technological advancements in cosmeceuticals and the associated increase in the use of cosmeceuticals in skincare. Nanotechnology is becoming an increasingly popular investment target for major corporations seeking to increase their market share through the introduction of innovative new products. The Mediterranean, Asian, African, and Latino populations are particularly susceptible to hyperpigmentation.
The harmful skin condition known as hyperpigmentation, which is fairly prevalent, can afflict anyone with any skin type. Despite the availability of numerous depigmentation active ingredients for the treatment of skin hyperpigmentation disorders, none of them are completely satisfactory due to poor permeation through the skin layer and significant toxicity, resulting in severe side effects such as irritant dermatitis, erythema, itching, and flaking of the skin. Nanotechnology contributes considerably to the advancement of cosmeceutical formulation by enhancing the solubility, stability, safety, loading efficiency, and skin permeability of active ingredients.
In addition to focusing on the improvement of the efficacy of certain active agents, researchers have examined how nanotechnology could improve the delivery of active components to the skin and their absorption by the body. Nanotechnology has emerged as an intriguing new addition to the cosmetic industry due to its capacity to enhance the quality of cosmetic products in general. Utilizing nanotechnology allows for the modification and enhancement of properties such as absorption, texture, protection of active substances, and overall efficacy.
It is likely that the efficacy of hyperpigmentation therapies could be enhanced by employing depigmentation-active chemicals such as hydroquinone, arbutin, kojic acid, azelaic acid, and retinoic acid; as well as innovative nanotechnology-based techniques. Nanotechnology is a viable method for topical hydroquinone delivery to reduce hyperpigmentation with adequate skin penetration and low systemic absorption, hence decreasing the possibility of hydroquinone-induced side effects.
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In 2021, the cosmeceuticals industry held a substantial chunk of the market share for available treatment options. The term "cosmeceuticals" refers to topical cosmetic-pharmaceutical formulations containing physiologically active substances. They have the capacity to enhance the appearance of the skin. Cosmeceuticals are rapidly gaining traction as a viable alternative to conventional treatments. It has been proven that phytochemicals, a form of cosmeceutical, have a variety of cellular effects for a number of dermatological disorders. Phytochemicals are chemical compounds derived from plants. Additionally, cosmeceuticals are commonly employed as a therapy for hyperpigmentation. Because hyperpigmentation disorders are notoriously difficult to treat, skin-lightening treatments, such as cosmeceuticals, may be necessary for therapy. These inhibit essential regulatory processes in the production of melanin and target hyperplastic melanocytes. In the majority of facial hyperpigmentation instances, cosmeceuticals are the treatment of choice because of their high absorption and skin penetration levels.
Melasma was the disease indication that led to the hyperpigmentation problem treatment market segment with the most share in 2021. Melasma is a disorder characterized by symmetrical hyperpigmentation that is typically developed over time and manifests most frequently on the face. This disorder is significantly more prevalent among women and people with darker skin tones. Pregnant women are particularly susceptible to melasma and other skin discolorations. Melasma is a disease that affects 15 to 50 percent of pregnant women. Melasma is a skin disorder that affects between 1.5% and 33% of the population. It presents itself most frequently throughout a woman's reproductive years and rarely during adolescence.
Between the ages of 20 and 40, this illness typically manifests. An increase in the incidence of melasma and an increase in the preference for cosmeceutical treatment have led to an increase in the demand for dermatological care. In the year 2020, around 5 million Americans were diagnosed with melanomas, making them a fairly common skin ailment. Up to thirty percent of Asian women of childbearing age suffer from melasma. This condition frequently reappears, rendering treatment ineffective. Understanding of the pathogenesis, clinical staging, and categorization, as well as the clinical treatment of melasma, has advanced significantly in recent years. The increasing prevalence of melasma and the expansion of accessible treatment options are two aspects that are expected to fuel growth in the hyperpigmentation disorders treatment market over the next few years, based on worldwide industry trends.
In 2021, aesthetic clinics and dermatological facilities held the greatest share of the global hyperpigmentation disorder treatment market in terms of end-user. During the projection period, it is anticipated that an expansion in the number of aesthetic clinics and dermatological centers will propel the sector. To meet the rising demand for hyperpigmentation problem treatments, manufacturers and distributors of cosmeceutical therapies for hyperpigmentation are enhancing their supply chains. Other global players and retailers are encouraging a variety of businesses to adopt an omnichannel supply strategy for their products in order to reach final consumers.
As a result of their ailments, patients with hyperpigmentary diseases, particularly melasma and post-inflammatory hyperpigmentation, endure tremendous social and mental distress (PIH). Melasma and PIH are difficult to treat due to their recurring and refractory nature, despite the fact that numerous treatment regimens have been devised for both disorders. Pigmentary disorders, including dermal or mixed melasma, are among the many dermatological conditions that can be treated with lasers. Lasers have revolutionized the treatment of certain dermatological disorders. With varying degrees of success, lasers have been widely used to treat pigmented diseases such as Becker's nevus, cafe-au-lait macules, Nevus of Ota, nevocellular nevi, lentigines, tattoos, melasma, and post-inflammatory hyperpigmentation. Lentigines have also been removed from the skin with lasers.
Asia-Pacific dominated the global hyperpigmentation disorder treatment market in 2021, accounting for more than 35% of the overall market. During the predicted time period, it is anticipated that the regional market will be extremely profitable. The market in the region is anticipated to be driven by factors including an increase in the adoption of laser treatment for several skin diseases, a decrease in social taboos and an increase in acceptance of treatment measures for pigmentation disorders, an increase in the prevalence of numerous skin disorders, a rise in awareness about skin rejuvenation, an improvement in lifestyle, and an increase in disposable income.
Variables such as geographical location, skin color, and age group influence the incidence of pigmentary disorders significantly. Approximately 6.9% of patients who participated in a Northern India study on childhood and adolescent dermatoses had pigmentary abnormalities. According to the findings of a study published in the 2018 issue of the International Journal of Molecular Sciences on populations of South/Southeast Asian, Hispanic/Latin American, and African heritage, darker-skinned persons have a higher prevalence of pigmentary disorders. These two disorders rank third and fourth, respectively, among the most prevalent dermatoses observed in African Americans and Hispanics. As a result, it is projected that the high prevalence of pigmentation disorders in this region will propel market expansion.
The market for hyperpigmentation therapies is very competitive and concentrated, with only a number of significant players dominating the market. Recent key strategies performed by the leading businesses in the global hyperpigmentation disorder treatment market include extending their product lines and investing in mergers and acquisitions. Aerolase Corporation, Candela Corporation, Cynosure, Galderma S.A., iSCLINICAL, ISDIN, L'Oreal (SkinCeuticals, Skin betterscience, and La Roche-Posay), LumenisBe Ltd., Mesoestetics, Obagi Cosmeceuticals LLC, PCA Skin, Scientis, Sente, and Skin are the leading companies in the global hyperpigmentation disorder treatment market respectively.
