Optogenetics: Market Growth, Future Prospects and Competitive Analysis, 2016 - 2023

The general concept of Optogenetics refers to the use of different genetically encoded probes for in vivo optical stimulation for studying neuroscience. Optogenetics is the emerging field of biotechnology that combines optical with genetic engineering to observe, analyze and control physiological functions in animal brain. Extensive research on optogenetics is being conducted in the fields of neuroscience, ophthalmology, cardiology, behavioral science and others.

This report studies the global optogenetics market on the basis of sensors, actuators, targeting techniques, applications and geography. Market size and forecast for each level of segmentation is being provided in this report for the period 2014-2023 with respective compounded annual growth rates (CAGR) for the forecast period 2016-2023. Based on sensors used, this market is studied for voltage-sensitive fluorescent proteins, genetically encoded calcium indicators, chloride sensors, pH sensors and neurotransmitter release sensors. Channelrhodopsin, Halorhodopsin and Archaerhodopsin are the actuators/effectors studied. The targeting techniques for optogenetics considered in this report include transgenic animals, viral vectors and cre-dependant expression system. Optogenetics finds application in neuroscience, behavioral tracking, retinal disease treatment and cardioversion and pacing.

Market size and forecast for these each regional are presented in this study for the period 2014-2023. Market growth rates for the forecast period 2016-2023 are also included in this report, considering 2015 as the base year.

Along with market estimation, qualitative information and assessment tools which are provided in the report depict better analysis of current market scenario and future trends. Data points such as drivers, restrains, and opportunities provide information related to current market dynamics influencing the market. The report also provides information on most attractive market during the forecast period along with competitive landscape of major players participating in the market. This report concludes with company profiles section that highlights major information about the key players engaged in optogenetics market.

Genetic targeting is a critical feature of optogenetics, which facilitates us to explore neurons at better resolution. Use of trans-synaptic trafficking has given us a novel technique with possibility to target specific axonal branches. Transgenic animals demonstrate uniform expression level. However, production of transgenic line is tedious effort and time consuming. Unlike transgenic animals that are restricted to rats and mice models viral vectors can be successfully used in higher organisms. Moreover, viral vectors is that these agents take short time to achieve transgene expression. As against transgenic animals, higher levels of transgene expression can be acquired by increasing transgene copy number. An issue with using viral vectors is that certain cell-type specific promoters exhibit weak expression levels. This drawback can be overcome with Cre-dependant expression system, which have a strong Cre-dependant promoter.

The discovery of NpHR and ChR2 and their potential application in neuroscience have created a surge in optogenetic research. Light-induced effectors allow for control of neural circuits at millisecond level. Such high temporal resolution of ChR2 and NpHR makes them a potential research tool. ChR2 and NpHR are stimulated by different light wavelengths, which allows  the two tools to be used together to control neural activity as per requirement. ChR2 is calcium permeable and as calcium influx is linked with neurotransmitter release, light induced reaction have a high chance of neurotransmitter release. ChR2 has been demonstrated to be useful in Parkinson’s disease treatment (linked with safety in with respect to long-term expression of ChR2). Much work needs to be done to determine safety of ChR2 expression in humans. Though several innovations in the field of optogenetic effectors have taken place in the past few years, the trend is further speeding up. This is still an early technology and further breakthroughs in this market are anticipated. 

VSFPs are expressed by cells, thus this allows them advantage from genetic targeting perspective. Initially, voltage-sensitive dyes were used for visualization of voltage changes, however, localized expression was difficult to achieve. VSFPs have higher precision compared to its precursors. Yet, there is very limited data available demonstrating the benefits of use of VSFPs. VSFPs are opined to have come to a stage where their potential will be effectively harnessed. A basic issue with using calcium levels as a parameter for action potentials is that some cellular processes use alteration of Ca2+levels. Hence, no matter how precise and sensitive GECIs are made, they still possess a risk of overestimating action potential. GECIs have been successfully used for assessment of synaptic and spiking activity across neurons. Further evolution in this field will increase information about mechanism of synaptic circuits.

North America and particularly United States is the largest market for optogenetics. Large-scale neuroscience and optogenetic research activities being conducted in North America. Optogenetics in North America is anticipated to follow the overall biotechnology market trends in the region. Europe is second in lead in terms of regional revenue. High awareness and breakthrough research activities being conducted in this region by both academic institutions and related companies. Asia-Pacific, Latin America and Middle East and Africa are still in the adoption stage of this technology. However, among these regions, Asia-Pacific is estimated to be the fastest developing regional market. Large-scale CRO activities being conducted in the region also allow the growth of Asia-Pacific optogenetics market.

Historical & Forecast Period

This study report represents analysis of each segment from 2022 to 2032 considering 2023 as the base year. Compounded Annual Growth Rate (CAGR) for each of the respective segments estimated for the forecast period of 2024 to 2032.

The current report comprises of quantitative market estimations for each micro market for every geographical region and qualitative market analysis such as micro and macro environment analysis, market trends, competitive intelligence, segment analysis, porters five force model, top winning strategies, top investment markets, emerging trends and technological analysis, case studies, strategic conclusions and recommendations and other key market insights.

Research Methodology

The complete research study was conducted in three phases, namely: secondary research, primary research, and expert panel review. key data point that enables the estimation of Optogenetics market are as follows:

• Research and development budgets of manufacturers and government spending
• Revenues of key companies in the market segment
• Number of end users and consumption volume, price and value.
• Geographical revenues generate by countries considered in the report
• Micro and macro environment factors that are currently influencing the Optogenetics market and their expected impact during the forecast period.

Market forecast was performed through proprietary software that analyzes various qualitative and quantitative factors. Growth rate and CAGR were estimated through intensive secondary and primary research. Data triangulation across various data points provides accuracy across various analyzed market segments in the report. Application of both top down and bottom-up approach for validation of market estimation assures logical, methodical and mathematical consistency of the quantitative data.

Key questions answered in this report

• What are the key micro and macro environmental factors that are impacting the growth of Optogenetics market?
• What are the key investment pockets with respect to product segments and geographies currently and during the forecast period?
• Estimated forecast and market projections up to 2032.
• Which segment accounts for the fastest CAGR during the forecast period?
• Which market segment holds a larger market share and why?
• Are low and middle-income economies investing in the Optogenetics market?
• Which is the largest regional market for Optogenetics market?
• What are the market trends and dynamics in emerging markets such as Asia Pacific, Latin America, and Middle East & Africa?
• Which are the key trends driving Optogenetics market growth?
• Who are the key competitors and what are their key strategies to enhance their market presence in the Optogenetics market worldwide?