Hot melt extrusion (HME) is the process of using heat and presser for melting polymer and continuously forcing the material through an orifice. HME process has been developed for producing polymer products with uniform shape and density and has been used in industrial application since the 1930s. Recently, HME technology has been brought in use in pharmaceutical application where it is dominantly used for manufacturing APIs with polymers to augment bioavailability or prepare precursors for thermoplastic drug eluting devices. This report discusses the principles of HME equipment in pharmaceutical manufacturing along with its future prospects and applications.
The purpose of this research study titled ‘Pharmaceutical Hot Melt Extrusion Equipment Market - Growth, Future Prospects, and Competitive Analysis, 2017 – 2025’ is to provide investors, developers, company executives and industry participants with in-depth analysis to allow them to take strategic initiatives and decisions related to the prospects in the global pharmaceutical hot melt extrusion equipment market. This report presents and analyzes the major trends prevalent in the global pharmaceutical hot melt extrusion equipment market and the market size and forecast.
This report categorizes the global pharmaceutical hot melt extrusion equipment market in terms of product type, usage area, and geographical distribution. Based on product type, the global pharmaceutical hot melt extrusion equipment market is categorized into ram extruders, radial screen equipment, and roll and screw extruders. The roll and screw extruders segment is further categorized into single-screw extruders (SSEs), twin-screw extruders (TSEs), and multi-screw extruders (MSEs). research and academia, contract manufacturing organization and pharmaceutical companies are the major usage areas considered for the purpose of this study. Market size and forecast for each mentioned segment for the period 2015-2025 is presented in the report along with respective CAGRs for the forecast duration 2017-2025.
The market size and forecast of each considered geographical market is presented for the period 2015-2025 along with CAGRs for the forecast period 2017-2025 in this study and are further cross-sectional presented in terms of product, usage area and constituent region/country level markets.
This report also includes qualitative assessment factors such as market dynamics (drivers, restraints and opportunities) to have a good understanding of the current and anticipated trends in the global pharmaceutical hot melt extrusion equipment market. Qualitative analysis of various application areas of pharmaceutical hot melt extrusion process is also presented in a separate chapter of the report. Competition assessment tools such as market attractiveness assessment and competitive landscape analysis by key players are also demonstrated in the study. Furthermore, this report concludes with profiling of key market players currently enjoying prominent position in the pharmaceutical hot melt extrusion equipment market. The key players profiled in this report are Baker Perkins Ltd., Coperion GmbH, Gabler GmbH & Co. KG, Milacron Holdings Corp., Leistritz Advanced Technologies Corp., Thermo Fisher Scientific, Inc. and Xtrutech Ltd.
Among the considered usage areas pharmaceutical companies and research and academia together are the largest segments in the pharmaceutical hot melt extrusion equipment market. Widespread adoption of hot melt extrusion systems in pharmaceutical production and perpetual urge to include more number of drugs under its coverage are the key factors contributing to the dominance of pharmaceutical companies. Hot melt extrusion is used to manufacture several drug delivery systems such as granules, pellets, oral fast dissolving systems, tablets (immediate and delayed release), transungual, transdermal and transmucosal delivery systems, and implants. Introduction of additional polymers to be combined in HME with APIs will open further avenues in the market.
TSE is the most widely used melt extrusion process used for solid dosage manufacturing. The TSE involves to agitator assemblies which permits different configurations from material feeding, rotating screw and conveying material to metered pumping zone. There are several types of TSEs available to fit distinct operating mechanisms and processing applications. The TSE screws can either rotate in the same direction or inverse. These TSE types are further categorized as fully intermeshing or non-intermeshing. Between these, the former is more commonly used because of its self-cleaning feature and prevention of localized overheating of raw material. The non-intermeshing variants are less popular and due to weaker screw system and less cleaning capability.
Geographically, the global pharmaceutical hot melt extrusion equipment market is cumulative to North America, Europe, Asia Pacific, Middle East and Africa and Latin America.
North America and Europe dominate the global pharmaceutical hot melt extrusion equipment market. Domicile of several prominent research centers and pioneer drug manufacturers mainly contribute to the dominance of North America market. Perpetual adoption of novel technical solutions in healthcare infrastructure and pharmaceuticals manufacturing and extensive research initiatives contribute to the dominance of Europe on the global front. Additionally, rapid proliferation of CMO activities in Asia Pacific, with growing base of skilled researchers will make Asia Pacific the fastest progressing regional market during the forecast period 2017-2025.
