Molecular weight markers are commonly known as DNA ladders, RNA ladders or protein ladders. The main function of the molecular weight markers is used for determination and identification of the molecular size of biological samples on gel electrophoresis by using the principle that molecular weight is inversely proportional to migration rate through a gel matrix. This method has undergone tremendous technological advancements and is now available in a wide range with loading buffer in a single tube, ready to use format which minimizes the time spent on thawing, diluting and adding the tracking dye to the DNA ladder.
For the purpose of this study, the various products studied are DNA markers, protein markers and RNA markers. DNA markers are further sub-segmented as (below 50 bp, 50 bp to 100 bp, 100 bp to 1 kb, 1 kb to 5 kb and above 5 kb). Protein markers are further classified as (below 10 kDa, 10 kDa to 100 kDa, 100 kDa to 200 kDa and above 200 kDa). The types of molecular weight markers considered in this study are unstained markers, prestained markers and specialty markers. The applications are categorized as nucleic acid applications and proteomics applications. Nucleic acid applications are further segmented as (PCR, Sequencing, Northern blotting, Southern blotting, molecular cloning and others). Proteomics applications are further classified as (Western blotting, gel extraction and others). Market size estimates and forecast of these segments for the period 2015 to 2025 are provided in terms of US$ Mn along with the respective CAGRs for the period 2017 to 2025, considering 2016 as the base year.
Market size estimates and forecast for these segments for the period 2015 to 2025 are provided in terms of US$ Mn along with the respective CAGRs for the period 2017 to 2025, considering 2016 as the base year.
This report also includes qualitative assessment factors such as market dynamics (drivers, restraints and opportunities) to have a good understanding of the current and anticipated trends in the global molecular weight markers market. Competition assessment tools such as market attractiveness assessment and competitive landscape analysis by key players are also presented in the study. Furthermore, this report concludes with profiling of key market players currently enjoying prominent position in the global molecular weight markers market. The key players profiled in this report are Agilent Technologies, Bio-Rad Laboratories, Inc., F Hoffman La-Roche Ltd, Merck KGaA, New England Biolabs, Promega Corp., QIAGEN, Takara Bio, Inc. Thermo Fisher Scientific, Inc., VWR International, LLC and other notable players.
The molecular weight market is driven by factors such as rising need for personalized medicine for the treatment of chronic diseases and rare diseases with genetic disorders Additionally, there has been enhanced funding in building the platform for optimum research to be carried out for proteomics and pharmacogenomics. Technological advancement in forensic haemogenetics where the DNA molecular weight markers are employed in forensic single locus probe analysis.
In 2016, DNA markers held the largest market share chiefly due to factors such as enhanced funding by the government agencies and biopharmaceutical giants to boost the research and development activities related to genomics where the DNA markers are employed for genome mapping. Protein markers will be the fastest growing market due to factors such as rising prevalence of rare diseases and increasing funding in the proteomics study for new drug discovery and companion diagnostics. RNA markers are used for the diagnosis and prediction of MicroRNA’s (miRNA), long noncoding RNA (lncRNA), noncoding RNA are aberrantly expressed in several cancers such as breast cancer, non-small cell lung cancers (NSCLC) etc. The major players in molecular weight market are Agilent Technologies, Bio-Rad Laboratories, Inc., F Hoffman La-Roche Ltd, Merck KGaA, New England Biolabs, Promega Corp., QIAGEN, Takara Bio, Inc. Thermo Fisher Scientific, Inc., VWR International, LLC.
In 2016, prestained markers held the largest market share chiefly due to factors such as its excellent performance in a variety of gel composition and concentrations, additionally it offers advantages such as to monitor the progress of an electrophoretic run, exceptional resolution, no thaw cycle required and no chemical reduction required before gel loading. Additionally, after the electrophoresis run, these prestained markers can be transferred from SDS PAGE gels to solid phase supports such as the polyvinyldiene difluoride (PVDF), nitrocellulose, nylon etc. Unstained markers will be the fastest growing segment throughout the forecast period. Its ability to accurately determine the molecular weight of the sample with uniform band intensities on SDS-PAGE gels stained with Coomassie Blue or zinc supports the growth of this segment. Few unstained markers are Strep-tagged that enable immunodetection of vectors in western blot techniques. Specialty markers offer a lucrative market opportunity due to increasing demand for PageRuler NIR Protein ladder for near IR fluorescent visualization and molecular weight estimation following electrophoresis. BenchMark His-tagged protein standard for its application in fluorescence molecular weight detection of his-proteins and also it is easily resolved with the ultraviolet light.
The molecular weight markers industry is witnessing tremendous growth significantly due to factors such as public-private partnership resulting in the expansion of research and development segment of pharmaceutical and biotechnology industries. Rare diseases diagnosis and treatment have been an eye catcher for the last decade leading to the incumbent demand for genome mapping to determine the biomarkers and targeted drug delivery to suppress the genetic factors responsible for the etiology of rare diseases.
In 2016, nucleic acid applications dominated the market. Factors such as increasing demand for the blotting techniques for the detection and transfer of DNA fragments onto a carrier allowing its use for gel electrophoresis drives this segment. Moreover, blotting techniques find huge application in gene discovery, DNA fingerprinting, diagnostics and forensics and the identification of transferred genes in transgenic individuals. The proteomics applications segment is anticipated to register faster growth throughout the forecast period 2017-2025, mainly attributed to rising prevalence of chronic diseases, increasing public health awareness resulting into early disease diagnosis and treatment. Proteomics study finds huge application in elucidating the additional components of biochemical pathways of microbes and analyze post-translational modification in the drug resistant bacteria.
North America was observed to be the largest market for molecular weight marker in the base year 2016. The dominance of North America is mainly attributed to the presence of large research laboratories specializing in biotechnology research and existence of evolved research and healthcare institutions. The market growth in Europe is mainly attributed to the increasing number of patients suffering with chronic and rare diseases. This factor boosts the demand for the determination of the biomarkers aberrantly present in the chronic diseases such as diabetes, cancer, cardiovascular complications etc., which could be expressed and targeted for the treatment. Asia Pacific is estimated to be the fastest growing regional segment throughout the forecast period 2017-2025. Factors that are anticipated to propel the market growth are presence of large patient pool that can be enrolled in biopsy studies for the determination of disease etiology and to test the drug treatment regimen during clinical trials, competitive market due to presence of existing major players and evolving biopharmaceutical companies involved in the manufacturing of molecular weight markers in this region, and supportive regulatory environment for molecular weight marker products. Moreover, factors such as developing health infrastructure and establishment of research centers by major biopharmaceutical companies are going to fuel the rapid growth of molecular weight marker market in Latin America, and Middle East and Africa in the near future.
Historical & Forecast Period
This study report represents analysis of each segment from 2022 to 2032 considering 2023 as the base year. Compounded Annual Growth Rate (CAGR) for each of the respective segments estimated for the forecast period of 2024 to 2032.
The current report comprises of quantitative market estimations for each micro market for every geographical region and qualitative market analysis such as micro and macro environment analysis, market trends, competitive intelligence, segment analysis, porters five force model, top winning strategies, top investment markets, emerging trends and technological analysis, case studies, strategic conclusions and recommendations and other key market insights.
Research Methodology
The complete research study was conducted in three phases, namely: secondary research, primary research, and expert panel review. key data point that enables the estimation of Molecular Weight Markers market are as follows:
Market forecast was performed through proprietary software that analyzes various qualitative and quantitative factors. Growth rate and CAGR were estimated through intensive secondary and primary research. Data triangulation across various data points provides accuracy across various analyzed market segments in the report. Application of both top down and bottom-up approach for validation of market estimation assures logical, methodical and mathematical consistency of the quantitative data.
| ATTRIBUTE | DETAILS |
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| Research Period | 2022-2032 |
| Base Year | 2023 |
| Forecast Period | 2024-2032 |
| Historical Year | 2022 |
| Unit | USD Million |
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Key questions answered in this report
